The role of Helicobacter Pylori in the development of ulcers
Helicobacter pylori (H. pylori) infection is present in approximately half of the world's population and the prevalence varies widely in Western countries and developing countries. The prevalence of H. pylori infection in Swedish people aged 30-50 years is around 30% and is higher in older age groups. Functional gastrointestinal disorders (FGID), such as functional dyspepsia (FD) and irritable bowel syndrome (IBS), are common pathologies of the gut.
FGID are clinical syndromes defined as chronic or recurrent pain or discomfort of unknown origin in the abdomen. The pathophysiological mechanisms responsible for FGID have not been fully elucidated, but ideas regarding its pathophysiology and the significance of the pathophysiology with respect to the symptom pattern of FGID have emerged. In particular, there is growing interest in alterations in gastric motility, such as accommodation to a meal or gastric emptying, and visceral sensation in FGID.
The mechanisms underlying impaired gastroduodenal motor function are unclear, but one possible factor can be H.pylori infection. H. pylori colonizes the human stomach causing gastritis and severe diseases including gastric cancer. The aim of the study is to study changes in the host (gastric mucosa) and in H. pylori in the same stomach over 18 years and H. pylori - impact on symptoms and inflammation during 18 years in the same stomach.
Kerstin Stake-Nilsson, University of Gävle
Peter Unge, Vice President, Head of FSCO, Novartis, Basel
Rolf Hultcrantz, professor, Karolinska University Hospital
Lars Engstrand, professor, Smittskyddsinstitutet, Solna